Department of Psychology

Genetic Variance in Ingestive Responses

The role of genetic variance in ingestive responses has been primarily studied by systematically comparing different inbred strains of mice with an outbred strain. In successive collaborations with Drs. Benjamin Kest (College of Staten Island) and Anthony Sclafani (Brooklyn College), our laboratory characterized the sensitivity, potency and magnitude of responses of 11 inbred (A/J, AKR/J, BALB/cJ, CBA/J, C3H/HeJ, C57BL/6J, C57BL/10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains for sucrose and fat (Intralipid) intake as well as for intake following regulatory glucoprivic (2-deoxy-D-glucose) and lipoprivic (mercaptoacetate) challenges. Our laboratory has also examined alterations in sucrose and Intralipid intake in eight (BALB/cJ, C3H/HeJ, C57BL/6J, C57BL/10J, DBA/2J, SJL/J, SWR/J, 129P3/J) and one outbred (CD-1) mouse strains following opioid and dopamine D1 and D2 receptor antagonism. Ongoing studies are examining whether genetic variance occurs for the development and strength of conditioned flavor preferences.

Genetic Variance Publications of the Bodnar Laboratory:

Iskhakova J, T Mustac, A Yuabov, J Macanian, E Israel, P Dohnalova, B Iskhakov, E Ben Lulu, S Aminov, D Fazylov and RJ Bodnar. Acquisition and expression of fat conditioned flavor preferences following dopamine D1, opioid and NMDA receptor antagonism in C57BL/6 mice. Nutritional Neurosci, in press, Jan 29: 1-10, 2020. (https://doi.org/10.1080/1028415x.2020.1724706).

Fazilov, G, M Shenouda, A Buras, B Iskhakov, D Bhattacharjee, P Dohnalova, J Iskhakova, FR Bourie and RJ Bodnar. Acquisition and expression of sucrose conditioned flavor preferences following dopamine D1, opioid and NMDA receptor antagonism in C57BL/6 mice. Nutritional Neurosci 23: 672-678, 2020. (accepted, Nov 22: 1-7, 2018: https://doi.org/10.1080/1028415x.2018.1544333).

Mustac T, A Yuabov, J Macanian, S Aminov, E Ben Lulu, D Fazylov, M Nashed, A Albakry, B Jean-Philippe-Morriset and RJ Bodnar. Acute D-fenfluramine, but not fluoxetine decreases sweet intake in BALB/c, C57BL/6 and SWR inbred mouse strains. Physiol Behav 224: 113029, 2020.

Iskhakov B, P Dohnalova, J Iskhakova, T Mustac, A Yuabov, J Macanian, E Israel, N Locurto, N Franz, G Fazilov, M Shenouda and RJ Bodnar. Murine genetic variance in muscarinic receptor antagonism of acquisition and expression of fat-conditioned flavor preferences in three inbred mouse strains. Pharmacol Biochem Behav 187: 172792, 2019.

LaMagna, S, K Olsson, D Warshaw, G Fazilov, B Iskhakov, A Buras and RJ Bodnar. Prior exposure to nutritive or artificial sweeteners differentially alters the magnitude and persistence of sucrose-conditioned flavor preferences in BALB/c and C57BL/6 inbred mouse strains. Nutritional Neurosci 22 (10), 706-717, 2019. (Accepted: 2/7/18: https://doi.org/10.1080/1028415X.2018.1436216).

Iskhakov B, FR Bourie, M Shenouda, G Fazilov, A Buras, D Bhattacharjee, P Dohnalova, J Iskhakova and RJ Bodnar. Murine genetic variance in muscarinic receptor antagonism of acquisition and expression of sucrose conditioned flavor preferences in three inbred mouse strains. Pharmacol Biochem Behav 172: 1-8, 2018.

Bourie, F, K Olsson, B Iskhakov, A Buras, G Fazilov, M. Shenouda, J Zhezherya and RJ Bodnar. Murine genetic variance in muscarinic cholinergic receptor antagonism of sucrose and saccharin solution intakes in three inbred mouse strains. Pharmacol Biochem Behav  163: 50-56, 2017.

Kraft TT, D Huang, S LaMagna, D Warshaw, E Natanova, A Sclafani and R J Bodnar. Acquisition and expression of fat-conditioned flavor preferences are differentially affected by NMDA receptor antagonism in BALB/c and SWR mice. Eur J Pharmacol 799: 26-32, 2017.

Kraft TT, D Huang, M Lolier, D Warshaw, S LaMagna, E Natanova, A Sclafani and R J Bodnar. NMDA receptor antagonism differentially reduces acquisition and expression of sucrose- and fructose-conditioned flavor preferences in BALB/c and SWR mice. Pharmacol Biochem Behav 148: 76-83, 2016.

Kraft, TT, D Huang, M Lolier, D Warshaw, S LaMagna, E Natanova, A Sclafani and RJ Bodnar. BALB/c and SWR inbred mice differ in post-oral fructose appetition as revealed by sugar versus non-nutritive sweetener tests. Physiol Behav 153: 64-69, 2016.

Kraft, TT, Y Yakubov, D Huang, G Fitzgerald, E Natanova, A Sclafani and RJ Bodnar. Dopamine D1 and opioid receptor antagonists differentially reduce the acquisition and expression of fructose-conditioned flavor preferences in BALB/c and SWR mice. Physiol Behav 151: 213-220, 2015.

Kraft, TT, D Huang, E Natanova, M Lolier, Y Yakubov, S LaMagna, D Warshaw, A Sclafani and RJ Bodnar. Dopamine D1 and opioid receptor antagonist-induced reductions of fructose and saccharin intake in BALB/c and SWR mice. Pharmacol Biochem Behav 131: 13-18, 2015.

Kraft TT, Y Yakubov, D Huang, G Fitzgerald, V Acosta, E Natanova, K Touzani, A Sclafani and RJ Bodnar. Dopamine D1 and opioid receptor antagonism effects on the acquisition and expression of fat-conditioned flavor preferences in BALB/c and SWR inbred mice. Pharmacol Biochem Behav 110: 127-136, 2013.

Bodnar, RJ, SR Lewis-Levy and B Kest. Feeding and drinking. Behavioral Genetics of the Mouse. Volume I: Genetics of Behavioral Phenotypes. Section 3: Autonomous and motor behaviors, Chapter 12. WE Crusio, F Sluyter, RT Gerlai and S Pietropaolo (Eds.) Cambridge University Press: Cambridge, United Kingdom, 97-108, 2013.

Dym, CT, T Kraft, V Bae, Y Yakubov, K Touzani, A Sclafani and RJ Bodnar. Double dissociation of D1 and opioid receptor antagonism effects on the acquisition of sucrose-conditioned flavor preferences in BALB/c and SWR mice. Pharmacol Biochem Behav 103: 26-32, 2012.

Pinhas A, M Aviel, M Koen, S Gurgov, V Acosta,  M Israel, L Kakuriev, E Guskova, I Fuzailov, K Touzani, A Sclafani and RJ Bodnar. Strain differences in sucrose- and fructose-conditioned flavor preferences in mice. Physiol Behav 105: 451-459, 2012.

Dym, CT, V Bae, T Kraft, Y Yakubov, A Winn, A Sclafani and RJ Bodnar. Genetic variance contributes to dopamine and opioid receptor antagonist-induced inhibition of Intralipid (Fat) intake in inbred and outbred mouse strains. Brain Res. 1316: 51-61, 2010.

Dym, CT, A Pinhas, M Robak, A Sclafani and RJ Bodnar. Genetic variance contributes to dopamine D1 and D2 antagonist-induced inhibition of sucrose intake in inbred and outbred mouse strains. Brain Res. 1257: 40-52, 2009.

Bodnar, RJ, SR Lewis and B Kest. Section 3.3: Feeding and drinking, Section 3: Autonomous and motor behaviors, Volume I: Behavioral Genetics of the Mouse. In: Encyclopedia of Behavior Genetics, WE Crusio, F Sluyter and RT Gerlai (Eds.) Cambridge University Press: Cambridge, United Kingdom, in press, 2010.

Dym, CT, A Pinhas, M Ginzberg, B Kest and RJ Bodnar. Genetic variance contributes to naltrexone-induced inhibition of sucrose intake in inbred and outbred mouse strains. Brain Res. 1135: 136-145, 2007.

Lewis, SR, C Dym, C Chai, A Singh, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of eleven inbred mouse strains for fat (Intralipid) intake. Physiol. Behav. 90: 82-94, 2007.

Lewis, SR, C Dym, M Ginzberg, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of mercaptoacetate-induced feeding in eleven inbred and one outbred mouse strains. Physiol. Behav.88: 516-522, 2006.

Lewis, SR, S Ahmed, E Khaimova, Y Israel, A Singh, Y Kandov, B Kest and RJ Bodnar. Genetic variance contributes to ingestive processes: a survey of 2-deoxy-D-glucose-induced feeding in eleven inbred mouse strains. Physiol. Behav. 87: 595-601, 2006.

Lewis, SR, S Ahmed, C Dym, E Khaimova, B Kest and RJ Bodnar. Inbred mouse strain survey of sucrose intake. Physiol. Behav. 85: 546-556, 2005.